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Early-phase clinical trials corroborate VCs safety profile and potential to ameliorate chemotherapy-induced fatigue and nephrotoxicity

They are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as well as in those who have a history of prior hypersensitivity reactions to semaglutide or any of the ingredients in the suspension

Semaglutide requires subcutaneous injection, meaning the needle enters the fat layer beneath the skin but does not reach muscle tissue

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism team

The accumulation of multiple unknown risks poses significant safety hazards

Ongoing pharmacovigilance continues to monitor for rare or unexpected adverse events as real-world use expands